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(3) Inhibiting Adipose Tissue Inflammation and Improving the Adipose Microenvironment In obesity, adipose tissue develops chronic lowgrade inflammation with abundant release of proinflammatory factors (such as TNF and IL6), disrupting the adipose microenvironment, further worsening fat metabolic abnormalities and insulin resistance, and forming a vicious cycle

10.1016/j.plaphy.2011.10.020 81 KogovsekP.Pompe-NovakM.BaeblerS.RotterA.GowL.GrudenK.et al

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Unlike many tissues in the body, cartilage has a limited ability to heal on its own

All three receptor pathways are maximally activated