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Before any experimental treatment was administered (time "-"), each mouse was initially tested with the hot-plate test to determine its basal reaction time-period

Preclinical and early clinical research into retatrutide has centered on its effects on body weight reduction, hepatic fat accumulation, insulin sensitivity, and appetite signaling

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Retatrutide-treated groups showed WOMAC pain reductions of up to 4.5 points, corresponding to roughly a 75.8 percent reduction in the pain score relative to baseline

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