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Pachetka A, Adamek B, Strzelczyk JK, Krakowczyk , Migula P, Nowak P, et al

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For this reason, the homeostasis of extracellular glutamate is tightly controlled by the combined activity of neuronal and glial membrane transporters, such as glutamate transporter-1 (GLT1), glutamate aspartate transporter (GLAST), and the cysteine/glutamate antiporter, or system xc (Sxc ), present in astrocytes, and EAAT3 present in neurons

Unfortunately, resistance to AmB has also been shown to be a concern in laboratory experiments

In particular, inhibitors or activators targeting cellular components, as well as biomolecules, enzymes, and nutrients, can stimulate apoptotic signaling pathways