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these factors make GLP-1 RAs an alternative initial treatment option, with or without metformin based on glycemic needs, in T2DM patients with indicators of high-risk or established heart failure (HF) or CKD who cannot tolerate an SGLT2 inhibitor

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NAD+ also supports DNA repair, cellular stress responses, and the regulation of inflammation, as well as the function of key longevity proteins called sirtuins