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Galectin-9 (Gal-9) is a ligand of Tim-3-driving apoptosis and peripheral immune tolerance when it specifically binds to Tim-3 on Th1 cells

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Somatostatin, in particular, has been shown to reduce total hepatic bile output, reduce bile acid secretion and stimulate the sphincter of Oddi, impairing bile flow [12]

Single-mechanism drugs target one cytokine or one receptor

67 WangL.LuK.LouX.ZhangS.SongW.LiR.et al (2023)