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683 Remarkably, the work summarized here on the superoxide dismutases (SODs) and ribonucleotide reductases (RNRs) reveal that cambialism and more generally metalloenzyme paralogs have evolved in enzymes that catalyze more restrictive chemistry, where a change in oxidation state and even access to high-valent intermediates, is involved

Singer P, Blaser AR, Berger MM, Calder PC, Casaer M, Hiesmayr M, et al

Tesfamariam, M., Vij, R., Trumper, V., Hube, B

APOE4 causes widespread molecular and cellular alterations associated with Alzheimers disease phenotypes in human iPSC-derived brain cell types

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Sub-2.5 mg dosing depends on product format, clinician supervision, and current compounding rules