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It is an appealing concept, but one that lacks direct clinical validation through controlled studies

pRTECs are interconnected by gap junctions and tight junctions, and when ferroptosis occurs in one cell, NADPH can simply diffuse from adjacent cells to the dead cell via cell junctions, thus making the adjacent cells less antioxidant and more sensitive to ferroptosis [101, 102]

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The null genotype of GSTT1 might be associated with increased toxicity after chemotherapy

Notably, in RA patients with low disease activity, a 12-week course of low-dose sirolimus (0.5 mg every other day) also exhibited a favorable safety profile, elevating Treg levels and enhancing clinical outcomes without evidence of toxicitiessuch as hemorrhagic cystitis or liver fibrosisthat are associated with certain conventional immunosuppressive agents (142)