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Due to the lack of fur, the abdominal temperature of Xpd TTD/TTD mice was several degrees higher than wildtype counterparts, an effect reduced by FOXO4-DRI (Fig

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Research shows that this can reduce the production of reactive oxygen species in the gastrointestinal tract

12 , e2202161 (2023)

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The best performing compound in the study, 92 , had an IC 50 value of 0.09 M and the positive control, allopurinol, 0.14 M, showing interesting potency (Figure 29)