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In a primary prevention study among 3,629 cognitively healthy older adults, the Prevention of Alzheimers Disease by Vitamin E and Selenium (PREADViSE) trial, vitamin E supplementation (400 IU/day of supplemental all - rac --tocopheryl acetate [180 mg/day of RRR --tocopherol]) for a mean of 5.4 years had no benefit on prevention of dementia (113)

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This may lead to an increased likelihood of insomnia and reliance on sleep aids

Increased slow oscillatory activity in substantia nigra pars reticulata triggers abnormal involuntary movements in the 6-OHDA-lesioned rat in the presence of excessive extracellular striatal dopamine

synthesized GSH-consuming nanoparticles using a reduction-sensitive amphiphilic polymer (P1), and encapsulated Pt (IV) prodrugs within the nanoparticles (Wang et al., 2021c)

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