However, these methods have limitations: pharmacological treatments mainly target pain relief with limited therapeutic efficacy
Other antioxidants like vitamin C or E dont bind NO with the same affinity, so they dont suppress enteric nervous system signaling to the same degree
In very high doses any supplement is capable of contributing to liver or kidney problems however, as explained above, generally NAC is considered protective of the liver and kidneys, not a harm to them
doi:10.1155/2015/574169 91
Normally, the liver removes extra copper through bile
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