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Barayeu U, Schilling D, Eid M, Xavier da Silva TN, Schlicker L, Mitreska N, et al

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Current clinical practice emphasizes personalized treatment plans tailored to each patients predominant clinical manifestations

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They thereby exceed considerably their original purpose, which was to document that the drugs do not increase cardiovascular risk

In this 2008 study, intrathecal (i.t.) administration of ALX5407 (doses of 10, 50, and 100 g) resulted in significant analgesic effects, with an increase in mechanical pain thresholds observed up to 240 min after administration