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However, some rare side effects of too much vitamin B12 can include: Headache Weakness Nausea Diarrhea Tingling sensations in the hands and feet Allergic reactions or skin rash (uncommon) When To Seek Medical Advice Risk of vitamin B12 deficiency: Groups at a higher risk of vitamin B12 deficiency include older adults, people who only eat plant-based foods (vegans and vegetarians), and those with certain chronic conditions (gastrointestinal disorders that can affect vitamin absorption)

Use sterile needles for injections

Avoid extrapolating animal dose by body weight without clinical guidance

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When suggesting a mechanism for thiamines benefit to Parkinsons patients, the researchers pointed to research showing decreases of a brain enzyme related to thiamine 8 as well as research showing lower thiamine levels in the spinal fluid of Parkinsons patients 9