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For instance, SIRT1 activators like SRT1720 and E1231 have been reported to improve hepatic steatosis and reduce inflammation in MAFLD models [15,16]

It's a negative feedback

It was included as a tertiary agent in the 2017 edition of the multi-agency clinical guidelines for the treatment of hypertension (Whelton et al, 2018), but was no longer mentioned in the 2025 AHA/ACC multisociety hypertension guidelines (Jones et al, 2025)

In the same podcast episode, he mentions that he used to take a supplement called phenibut, which was a more effective means of achieving these same ends, but that substance was banned by the FDA

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