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Steiner et al., 2018

Cell Metabolism 2022: 10.1016/j.cmet.2022.07.002 receptor binding constants (GIP EC50 0.0643 nM, GLP-1 0.775 nM, glucagon 5.79 nM)

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This impairment of DNA synthesis affects the rapidly dividing cells of the bone marrow earlier than other cells, resulting in the production of large, immature, hemoglobin-poor red blood cells (macrocytosis), as well as effects on white blood cells, including abnormal (hypersegmented) neutrophils and reduced overall cell counts (pancytopenia)

However, the causal relationship between gut microbiota dysbiosis and pulmonary infections could potentially be bidirectional: in immunosuppressed or chronically ill patients, microbiota dysregulation may enhance susceptibility to pneumonia by impairing mucosal immunity

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