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Vitamin B12, also known as cobalamin, is a crucial water-soluble vitamin that plays an essential role in red blood cell formation, nerve function, and DNA synthesis

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Collectively, it may be hypothesized that obesity induces feedback inhibition of pituitary GH secretion by increasing non-fasting serum FFA levels and the associated insulin resistance that causes compensatory intra-portal hyperinsulinemia and IGFBP-1 suppression, with the net result being low GH and normal IGF-I levels

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Human healthspan requires outcomes such as mobility, cognition, independence, cardiovascular events, cancer risk and quality of life