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Conclusion This article has discussed some of the basic evidence implicating these putative orexigenic and anorexigenic peptides in the complex regulation of body weight, appetite, and energy homeostasis

Furthermore, neuroinflammation can induce aggravating factors such as bloodbrain barrier disruption, altered neurotransmitter metabolism, oxidative stress, and neurodegeneration [38]

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At mitochondrial level, structural integrity and energy function of this organelle are affected, triggering the apoptosis cascade