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This is a major reason for the poor prognosis of colorectal cancer when compared to any single therapy

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ATXN3 colocalizes with aggresomes and preaggresome particles of the misfolded cystic fibrosis transmembrane regulator (CFTR) mutant CFTRF508 and interacts with proteins involved in their formation and regulation, such as dynein and histone deacetylase 6 (HDAC6)