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Despite our sample being approximately sixfold smaller than the British GWAS 16 , we robustly replicate their findings that the UGT2B10 locus on chromosome 4 is associated with N -desmethylclozapine serum concentration, and hence the CLZ-to- N -desmethylclozapine metabolic ratio

DOI: 10.1161/01.CIR.83.1.1 12

Neuropsychopharmacology 38:11131120 Jasinska AJ, Zorick T, Brody AL, Stein EA (2014) Dual role of nicotine in addiction and cognition: a review of neuroimaging studies in humans