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REFERENCES Manifestations of fatigue that may occur when status or supplies of these micronutrients are not adequate. Consuming adequate intakes of vitamins and minerals contributes to maintenance of normal cognitive function and to enhanced well-being by decreasing perceived mental and physical fatigue and favoring positive mood

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Konczol et al 2016), resulting in only non-psychoactive peripheral sympathomimetic effects following ingestion

Quick Answer: Yes, you can generally take Vitamin C while on Accutane