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Other mechanisms like mutations that enhance cytosolic levels or intensify intracellular signaling have also been associated with ASD (Krey and Dolmetsch, 2007)

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66,67,189 An uncontrolled trial in 22 treatment-resistant patients with Mnire disease evaluated oral administration of 300 mg per day rebamipide (an oxidative stress medication not available in the United States) along with 600 mg per day vitamin C and/or 300 mg per day glutathione for eight weeks