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However, this iron accumulation does not trigger iron-induced cell death

The net effect of ERR activation is increased mitochondrial mass and function, enhanced oxidative capacity, greater fatty acid utilization, and improved metabolic flexibility

Funding This work was supported, in part, by grants from the National Institute of General Medical Sciences (R35GM147101) to P.M., and the Breast Cancer Research Foundation of Alabama to P.M

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Badurek, S

Beyond direct -cell protection, butyrate exerts indirect protective effects by modulating immune responses and promoting the differentiation of Tregs that shield pancreatic -cells from cytokine-induced damage (189, 190)