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Worldwide now have diabetes mellitus, 80 to 90% of whom have T2D (Zheng et al., 2018), and GD affects 5 to 10% of pregnant women (Ross, 2006)

Evidence from several rodent (Reference Kumar and Rizvi12Reference Zhu, Carvey and Ling14) , dog (Reference Park, Mathison and Hayek15,Reference Vajdovich, Gal and Szilgyi16) and human (Reference Ferguson and Bridge17Reference Sekhar, Patel and Guthikonda21) studies suggests that glutathione levels in organs, erythrocytes and plasma decline with age

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With a deeper understanding of ferroptosis during the occurrence and progression of cerebral I/R injury, new therapies to treat ischemic nerve damage by interfering with the molecular mechanism of ferroptosis are expected to be realized to some extent