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Stroke 52 , 595602 (2021)

[15] In 1908, Japanese researcher Kikunae Ikeda of the Tokyo Imperial University identified brown crystals left behind after the evaporation of a large amount of kombu broth as glutamic acid

FAE mediate their anti-psoriatic effects via activation of several cellular pathways that induce T-cell apoptosis or prevent release of proinflammatory cytokines (Figure 1)

Stockler-Ipsiroglu S, Apatean D, Battini R, DeBrosse S, Dessoffy K, Edvardson S, Eichler F, Johnston K, Koeller DM, Nouioua S, Tazir M, Verma A, Dowling MD, Wierenga KJ, Wierenga AM, Zhang V, Wong LJ (2015) Arginine:glycine amidinotransferase (AGAT) deficiency: clinical features and long term outcomes in 16 patients diagnosed worldwide

J Clin Oncol 35(29):3354-3362, 2017

4 Various oxygen radical stresses have been shown to result in GSSG formation and short-term depletion of GSH