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Skipping sun protection: UV radiation destroys collagen faster than GHK-Cu can build it

They also interact with structurally related receptors

Cu Transport Enzymatic Activity Copper & Antioxidant Delivery The GHK-Cu complex delivers copper to cells, activating superoxide dismutase (SOD) and key wound-healing enzymes (lysyl oxidase)

The Nrf2-independent effect of these inducers could result from their ability to activate additional transcription factors that are also able to increase GST expression, such as the pregnane-X-receptor (PXR), which in turn activates ARE signaling (reviewed in [32])

That's when you know it's already inside your skin

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