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The liver produces high levels of thiomethyl metabolites from glutathione conjugates We then used in vitro liver models (HepaRG-HRG-and primary human hepatocytes-PHH) to provide a better understanding of the formation of these thiomethyl metabolites (in particular to identify their precursors), and a better understanding of the site where the biotransformation occurs

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The D-2-naphthylalanine (D-2-Nal) at position 3 a bulky, non-natural amino acid provides critical receptor binding contributions and contributes to selectivity

In addition, the phytochelatins (PCs) are a polymerized version of GSH involved in HMs detoxification by functioning as chelating ligands [6]

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It also gives laboratories a clearer way to separate this format from single-compound products that do not offer the same paired-pathway perspective