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Supportive Therapies To maximize AOD-9604s metabolic benefits, consider integrating: Structured nutrition protocols: Moderate caloric deficit (15-20% below maintenance), adequate protein intake (0.8-1.2 g/lb body weight) to preserve lean mass, strategic carbohydrate timing around training, and whole-food focused diet to support overall metabolic health
Animal toxicology studies have generally shown low acute toxicity at studied doses, but long-term safety data in humans are absent
AOD 9604 directly affects the fat metabolism without affecting hormone and insulin levels
Insulin, for example, is a peptide, as are widely used GLP-1 medications for diabetes and obesity such as Ozempic and Wegovy
Once inside adipocytes and other metabolically active cells, the compound binds to the NNMT active site, preventing the enzyme from converting nicotinamide to 1-MNA
