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Side effects of IV glutathione The abuse of glutathione for skin lightening in the pregnant population is a concerning issue that has led the African nation of Ghanas FDA to issue a warning stating it can cause congenital disabilities

For instance, the activation of NF-B and NLRP3 pathways leads to massive cytokine release (143)

An amino acid derivative that plays a critical role in energy production by transporting fatty acids into mitochondria for fuel

Beside scavenging free radicals and recycling the other antioxidants, glutathione is needed for phase 2 liver detoxification and also plays a very important role in immune function, specifically the specialized immune cells of the brain, called glial cells

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Moreover, macrophages express C-C chemokine receptor 2 (CCR2) to which CCL2 can bind, thereby inducing macrophage secretion of the pro-inflammatory mediators, IL-1, TNF, IL-12, and CXCL10