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intermittent treatment with senolytics have conclusively reduced senescent cell burden in peripheral tissues (fat, lung, kidney, pancreas, cartilage, and muscle), improved pathologies in these tissues, and extended healthspan and lifespan (45, 46, 100103)

FuBLiaoJChenSLiWWangQHuJet alCrispr-Cas9-mediated gene editing of the Bcl11a enhancer for pediatric Beta(0)/Beta(0) transfusion-dependent Beta-thalassemia

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Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide