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Circulating markers of NADH-reductive stress correlate with mitochondrial disease severity

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Inflammation cytokines (e.g., TNF-, IL-1) abundant during HIV infection exacerbate mitochondrial dysfunction and ROS production, forming a self-amplifying loop that increases mtDNA damage (85)

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Both models excluding the subjects with ESRD occurring within 3 years (adjusted HR 1.989, 95% CI 1.7462.256) and 5 years (adjusted HR 1.944, 95% CI 1.6232.328) demonstrated a significant association between RA and the risk of ESRD, suggesting the least likelihood of reverse causation