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The water-splitting activity of PSII facilitates the transfer of elections through the PET chain to produce reduced ferredoxin and NADPH, and also produces molecular oxygen

This mitochondrial failure results in the immune senescence of those same T cells and a systemic accelerated aging phenotype, marked by motor deficits, cardiovascular dysfunction, and cognitive decline (Desdn-Mic et al., 2020)

Several developments suggest we are still in the early chapters of this story

Moffitt Cancer Center Basic Science Grand Rounds

Sites of action of important transcription factors are not shown

NAC, which increases glutathione levels in the brain, improved symptoms of schizophrenia in clinical studies [22]