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If you ingest an artificial sweetener, say, drink diet soda while consuming foods that increase blood glucose, then later, even if you just drink the diet soda, it's been shown that you secrete much more insulin, the hormone that regulates blood glucose, in response to that diet soda
Carson SA, Kallen AN
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Pain Signaling and Neuromodulation Models DSIP has been examined in experimental models of nociception and central pain processing
Microbial ecology: human gut microbes associated with obesity (in Eng)