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Indoleamine 2,3-dioxygenase negatively regulates mTORC1 signal transduction via PTEN, preventing proliferation of Teffs and promoting induction of Tregs [62, 64]

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These results suggested that the model was successfully established (Korkmaz et al., 2023)

Therefore, systematically examining these gaps in evidence is crucial for objectively assessing the reliability of this framework and guiding confirmatory studies

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Choline, for example, is involved in lipid transport and metabolism (a vital part of energy storage), cell membrane signaling, and nervous system function