How Do glucocorticoids influence stress responses
Jobin et al., 1999
doi: 10.1210/jc.2012-4262
In vivo , in the hippocampal tissues of mice exposed to PS-MPs, there was a significant increase in the mRNA expression levels of inflammation-related genes ( Tnf-a , Il-1b , Il-6 , Cxcl10 , and Mcp-1 ), indicating heightened inflammatory responses ( In vitro studies indicate PS has the capacity to bind to and activate BV2 microglial cells, thereby inducing pro-inflammatory reactions and activating inflammatory pathways, such as the NF-B pathway, which results in the production of pro-inflammatory cytokines ( in vitro and in vivo evidence converge to highlight oxidative stress and subsequent neuroinflammation as pivotal events in MPs-induced neurotoxicity
Chamomile: Reduces inflammation and irritation
Therefore, clinical testing in controlled populations is ultimately required to assess whether this preclinical efficacy is also observed in patients with CRC, both first-line in high-risk patients with high oxidative metabolic signalling (Fig
