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Despite being weak bases, the aminoglycosides are very large, hydrophilic molecules and have high pKa values, so they are highly ionized at physiologic pHs

[DOI] [PMC free article] [PubMed] [Google Scholar] 33.Zou M., Hu X., Xu B., Tong T., Jing Y., Xi L., Zhou W., Lu J., Wang X., Yang X., et al

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