Receptor Sensitivity: The Why Behind Cycling Just like insulin receptors can become resistant with constant sugar exposure, peptide receptors can downregulate or desensitize if overstimulated
Unlike muscles or skin, discs have very limited blood supply
Under the influence of a leaky epithelial barrier, the immune system is locally activated and inflammation develops, which can be transmitted via immune cells and the cytokines they secrete to other systems and organs
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
The effect of infections on susceptibility to autoimmune and allergic diseases
Doses at the higher end of the range (0.50 mg twice daily) with longer cycles (10 to 12 weeks) represent common approaches for more significant injuries
