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Some research protocols account for this by using comparatively lower dosing ranges in female study cohorts, reflecting a generally increased sensitivity to IGF-1 receptor activation a pattern also documented in broader growth hormone axis research, not unique to IGF-1 LR3 specifically

Reactive oxygen species in ovarian physiology

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doi:10.1073/pnas.242603899

[DOI] [PubMed] [Google Scholar] 109.Zametkin A.J., Nordahl T.E., Gross M., King A.C., Semple W.E., Rumsey J., Hamburger S., Cohen R.M

That's the typical pathway for this demographic: topical exposure first, then discovery of systemic protocols, then a clinical consultation to make sense of the gap between the two