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The force for most of the transporters (on the sinusoidal or canalicular membranes) is generated by a sinusoidal Na + /K + ATPase pump (pumps sodium into the cell and potassium into the extracellular fluid or blood)

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This has called for new emerging strategies for improved bioavailability that include chemical modifications to stabilize the peptide, use of enzyme inhibitors, linkage to absorption enhancers, and packaging peptides using nanoparticles