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Deferoxamine, the first FDA-approved drug in 1968 (Parker et al., 2023), is administered via intravenous (IV) or intramuscular (IM) injection due to its poor oral bioavailability, which is one of the most significant limitations of the DFO treatment ( A = 4 10 16 ) allows it to be the standard of care for acute iron toxicity for decades (Maggio et al., 2011)

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