As an endogenous switch for the control of signaling cascade pathways, elevated expression of GST can alter the balance of regulation of kinase pathways during drug treatment, thereby, conferring a potential selective advantage
Endocrinology (1999) 140(11):517884.10.1210/endo.140.11.7151 309 HolderATSpencerEMPreeceMA
[90] demonstrated that anti-IL-17 antibody treatment alleviated allergic symptoms, decreased inflammatory cell infiltration, and elevated the Treg cell population and function while decreasing the Th17 and Th2 cell populations in AR mice
These increase inflammation and cause oxidative damage and impaired glutathione production
160 WaszkiewiczN.SzajdaS
The compound shows high enzymatic selectivity, preserves lean mass, and engages longevity-related pathways (e.g., SIRT1), but remains a nonFDA-approved research substance that is WADA-banned and should be used under medical guidance