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Before 1990, clinicians performed most injections blindly, that is, using anatomic landmarks that can be seen with the eye (observed) and felt with the hands (palpated)

This reduction in inflammation promotes healing and improves overall hand function

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Biochem Biophys Res Commun 209:227233 Mulcahy RT, Untawale S, Gipp JJ (1994) Transcriptional up-regulation of gamma-glutamylcysteine synthetase gene expression in melphalan-resistant human prostate carcinoma cells