Some researchers have identified the main efflux transport proteins of SL was multidrug resistance-associated protein (MRP2) and breast cancer resistance protein (BCRP), and compounds that inhibited the efflux transport proteins MRP2 and BCRP could enhance the absorption and activity of SL (Xie et al., 2019), such as piperine or tangeretin (Yuan et al., 2018)
Coordinated action of glutathione S-transferases (GSTs) and multidrug resistance protein 1 (MRP1) in antineoplastic drug detoxification
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Skin brightening : Known for its skin-lightening effects, Glutathione is largely used to treat hyperpigmentation and melasma
This is supported by transcriptional profiling of resistant field isolates having changes linked to redox metabolism 20
Protein-sulfenic and glutathione sulfenic acids result from reaction with endogenously produced ROS or RNS but usually these species are rapidly transformed in prot-SSG (GSSR) or GSSG as more stable derivatives
