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The dissolved nicotine then penetrates the oral mucosa, entering small blood vessels beneath the surface

In addition, smoking was linked to a greater induction of the cytokines interleukin (IL-)2 and IL-13 after stimulation with the T cell activator Staphylococcus aureus enterotoxin B superantigen (SEB)

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A severe lung condition known as E-cigarette or Vaping Product Use-Associated Lung Injury (EVALI) has also been identified, characterized by symptoms like shortness of breath, cough, and chest pain, and in some cases, leading to hospitalization and death

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