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Studies in metabolic disease consistently report elevated systemic LPS levels associated with dysbiosis and metabolic endotoxemia ( + and XBP1 + subclusters and the downregulation of maturity-related transcription factors such as PDX1 and MAFA under inflammatory conditions (Sokolowski et al., 2024)

However, studies in mice show NR is more effectively taken up than NMN in some tissues, such as skeletal muscle 39 , highlighting the importance of the choice of precursor treatment depending on the intended target organ

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This evidence is key to understanding their role in regenerative medicine

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