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Suprachiasmatic nucleus (SCN)

Our findings manifested that deficiency of Nrf2 substantially attenuated the rescue effect of metformin on OA development in MIA-induced mouse model (Figs

3.2.1 Nutrient Sensing and AMPK Activation IF reduces nutrient availability, leading to lower insulin levels and suppression of mechanical target of rapamycin (mTOR) signaling, a pathway that typically inhibits autophagy in the fed state

doi: 10.1136/bjsm.2006.030585

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painful resisted flexion of wrist, occasionally resisted pronation of forearm