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To improve its stability, L 11 was further passaged to obtain ToMV-L 11 A (hereafter, L 11 A), which showed milder symptoms in tomato plants

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Palate cleansers like citrus, ginger, and sparkling water help shorten the duration

Psychosocial stress (e.g., giving subjects a demanding task and distracting them at the same time) caused an increase in the stress hormones epinephrine and cortisol, but the addition of a moderate amount of caffeine more than doubled the stress response.19 Importantly, the researchers found that habitual and light caffeine consumers had basically the same increase in stress hormones, proving that people do not develop a tolerance to the anxiety-producing effects of caffeine

They can develop into full-blown cancer

So yeah, not exactly a rolling anvil