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The storm clouds over Pinar del Ro, in the west of the country, may hurt sales this year, along with other problems like tough anti-tobacco laws in Europe and the economic blockade imposed by the United States on Cuba because of the of conflict between Washington and Havana that has gone on for half a century
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Moreover, although claudin-5 was up-regulated (see Figure 5) the pattern of expression presented as an homogenous distribution throughout the cells and lacked a demarcated membrane localization which does not suggest improvements of cell-cell adhesion
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