The first is Huppke-Brendel Syndrome, a severe neurodevelopmental disorder characterized by severe intellectual disability, motor deficits, and progressive neurodegeneration
2) the data was already published in another article identified in the search
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doi: 10.1016/j.cell.2024.01.030 19 ConradMPrattDA
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Furthermore, a placebo-controlled randomized trial evaluated the efficacy of folinic acid (5 mg twice daily) for 12 weeks in 19 children aged 310 years (sex distribution not reported) with ASD diagnosed by ADOS, without genetic syndromes, major medical comorbidities, or treatments affecting folate metabolism
