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This results in potent anti-tumour activity in preclinical models where drug sensitivity is strongly associated with levels of accumulated mut-p53 protein 3

3.1 Ferroptosis influences intestinal diseases by affecting inflammation Effects of ferroptosis on intestinal diseases linked to inflammation are listed in Table 4

Piksa M

This review also summarizes and highlights current limitations in targeting the Th17/Treg balance for AR treatment and suggests future research directions, aiming to provide new insights and strategies for clinical management (Fig

& Tani, N

ACTL6A impacts GSH de novo synthesis mainly by upregulating -glutamyl-cysteine synthesis To further assess the mechanism by which ACTL6A regulates GSH metabolism, we investigated the metabolic fate of U- 13 C glucose by liquid chromatography with mass spectrometry (LCMS), which produces -GC containing two 13 C atoms via GSH de novo synthesis pathway, GSH containing two 13 C atoms via GSH de novo synthesis or the SGOC pathway, or four 13 C atoms via both pathways (Fig