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This peptide inhibited TGF-1/Smad2/3 and STAT3 pathways, leading to decreased inflammation, tubular atrophy, myofibroblast activation, and fibrotic gene expression (Gwon et al., 2021)

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At the population level, the overall trajectory was one of disease progression rather than improvement: the mean MELD-3 score increased by 2.69 points from baseline to follow-up along with statistically significant changes indicating hepatic decompensation

Cortical spreading depression causes and coincides with tissue hypoxia