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At present, there is no definitive evidence of the interaction between the circadian clock system and the GH/IGF-1 axis and the pathophysiological mechanism causing metabolic disorders

Novo Nordisk filed a New Drug Application for the CagriSema combination (cagrilintide 2.4 mg + semaglutide 2.4 mg) in December 2025, with an FDA decision anticipated in late 2026

Singh et al., 2023)

Decorin is a proteoglycan that organizes collagen fibers into stronger, more resilient structures

Altogether, these studies suggest that both melatonin and treatments aimed to remodulate circadian homeostasis hold promise not only in enhancing treatment efficacy and quality of life, but also in potentially counteracting immunosuppressive and pro-metastatic mechanisms driven by circadian disruption in BC patients

Supplementary prognostic variables for pleural mesothelioma: a report from the IASLC staging committee